Ghobrial Lab Mission
To identify patients at risk of progression to B cell malignancies from early precursor conditions such as Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM) and develop targeted therapies to eliminate the disease before it progresses.
To identify mechanisms of progression in Multiple Myeloma. We examine the genetic, epigenetic, and immune alterations that regulate tumor dissemination and the role of the bone marrow niche in disease progression.
To identify mechanisms of progression in Multiple Myeloma. We examine the genetic, epigenetic, and immune alterations that regulate tumor dissemination and the role of the bone marrow niche in disease progression.
Current Projects
- The effect of Elotuzumab on cell-trafficking, homing, adhesion and proliferation of multiple myeloma cells within the bone marrow niche
- Deciphering and targeting clonal evolution in hematologic malignancies
- Stoma-mediated clonal evolution in multiple myeloma
- Immune regulation and precursor conditions in multiple myeloma
- Ultra-rare cell in vivo flow cytometry
- Immunotherapy to prevent progression in multiple myeloma
- Molecular profiling of smoldering myeloma
|
|
|