Ghobrial Lab Research
Our research focuses of hematological malignancies and their precursor conditions. Our current projects include:
- Factors that regulate disease progression in patients with MGUS/SMM to overt MM.
- Understanding progression risk and identifying patients with precursor disease who would benefit most from early intervention.
- Identifying novel immunotherapy targets and strategies in MM and MUGS/SMM.
- Mechanisms of early cell dissemination and clonal heterogeneity.
- The use of circulating tumor cells and cell-free DNA as disease biomarkers.
- Defining the role of the bone marrow niche in regulating clonal evolution and disease progression.
- Identifying novel biomarkers of disease progression in precursor hematological malignancies.
- Examining the cell-cell interactions of plasma cells in MM.
- Therapeutic targeting of the bone marrow niche and interception of disease progression in myeloma.
- Examining novel targets in clinical trials in Multiple Myeloma and Waldenstrom Macroglobulinemia (WM).
- The role of the bone marrow niche in regulating drug resistance in MM.