Ghobrial Lab Research

Our research focuses of hematological malignancies and their precursor conditions.  Our current projects include: 

• Factors that regulate disease progression in patients with MGUS/SMM to overt MM.
• Understanding progression risk and identifying patients with precursor disease who would benefit most from early intervention.
• Identifying novel immunotherapy targets and strategies in MM and MUGS/SMM.
• ​Mechanisms of early cell dissemination and clonal heterogeneity.
• The use of circulating tumor cells and cell-free DNA as disease biomarkers.
• Defining the role of the bone marrow niche in regulating clonal evolution and disease progression.
• Identifying novel biomarkers of disease progression in precursor hematological malignancies. 
• Examining the cell-cell interactions of plasma cells in MM.
• Therapeutic targeting of the bone marrow niche and interception of disease progression in myeloma.
• Examining novel targets in clinical trials in Multiple Myeloma and Waldenstrom Macroglobulinemia (WM). 
• The role of the bone marrow niche in regulating drug resistance in MM.