Ghobrial Lab Research

Our current research focuses around multiple aspects of cell metastasis or cell dissemination in hematological malignancies and their interactions with the bone marrow niches including: 

• Mechanisms of early cell dissemination and clonal heterogeneity.
• The role of circulating tumor cells and circulating exosomes in cell dissemination.
• Preparation of the metastatic niche for tumor colonization.
• Factors that regulate progression of micro-metastasis in patients with MGUS to overt MM.
• miRNA regulators of tumor dissemination and stromal/myeloma interaction for cell dissemination.
• Mechanisms of cell dissemination in extramedullary MM.
• The role of the bone marrow niche in regulating drug resistance in MM.